#1
Posted: Fri Mar 13, 2026 3:40 pm
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect strategy to counter KRAS-driven malignancy without direct KRAS targeting.
Source: https://medicalxpress.com/news/2026-03- ... ancer.html
Source: https://medicalxpress.com/news/2026-03- ... ancer.html