Major depressive disorder (MDD) is a debilitating condition that affects more than 246 million people worldwide, yet scientists have struggled to identify consistent brain markers that could improve diagnosis and treatment. Finding reliable neurobiological markers for MDD has been hampered by the methodological differences observed across neuroimaging studies. Traditional brain imaging studies have produced conflicting results, often due to differences in methods and analysis pipelines. This inconsistency has made it difficult to pinpoint reliable neurobiological signatures of depression.
Source: https://medicalxpress.com/news/2026-02- ... ssive.html
