Researchers have uncovered the enzyme behind chromothripsis, a chaotic chromosome-shattering event seen in about one in four cancers. The enzyme, N4BP2, breaks apart DNA trapped in tiny cellular structures, unleashing a burst of genetic changes that can help tumors rapidly adapt and resist therapy. Blocking the enzyme dramatically reduced this genomic destruction in cancer cells.
Source: https://www.sciencedaily.com/releases/2 ... 225546.htm
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